Histological Study for the Effect of Squalene Supplements on Muscles Rats Treated with Simvastatin
DOI:
https://doi.org/10.59658/jkas.v10i2.1189Keywords:
Squalene, simvastatin, cholesterol, histopathological studies in musclesAbstract
The present study aimed to reveal the biological vitality of squalene supplements and in combination with statins. Statins are a class of drugs that are regularly administered to decrease cholesterol. The main cause of statin discontinuation is the development of statin-associated muscle symptoms. Because of the statin-related myotoxicity phenotypes that are getting worse have been proposed, the study was conducted to examine the effects of squalene supplements in combination with statin. In the experiment, thirty male rats were divided into two group, (experimental one) five rats dosage with normal saline only and other rats administrated with cholesterol 1%/BW for 28 days. Then the second group was randomly divided into four groups (experimental two). The experiment lasted about during two months, the rats were administration as the following groups, first group: six rats used as a negative control group dosage with normal saline only; second group: six rats used as a positive control group dosage with normal cholesterol 1% only; third group: six rats administrated with cholesterol 1%/BW for 28 days then treated with simvastatin 40 mg/kg dosage orally every day for 4 weeks; forth group: six rats administrated with cholesterol 1%/BW for 28 days then treated with squalene 0.2 mg orally every day for 28 day, and fifth group: six rats will have administrated with cholesterol 1%/BW for 28 days then treated with simvastatin 40 mg/kg dosage orally with squalene every day for 28 day. In conclusion: we found from the study effect of squalene supplements on rats treated with statin to avoid side effect and protecting the muscles from damage caused by statin.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Journal of Kerbala for Agricultural Sciences
This work is licensed under a Creative Commons Attribution 4.0 International License.
Licensing Terms
All articles are published under a Creative Commons License and will be directed to the Creative Commons Attribution 4.0 International License That permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Use by non-commercial users
For non-commercial and non-promotional purposes individual users may access, download, copy, display, and redistribute the articles to colleagues, as well as adapt, translate, text- and data-mine the content subject to the following conditions:
- The author's moral rights are not compromised. These rights include the right of "paternity" (also known as "attribution" - the right for the author to be identified as such) and "integrity" (the right for the author not to have the work altered in such a way that the author's reputation, or integrity may be impugned).
- Where content in the article is identified as belonging to a third party, it is the obligation of the user to ensure that any reuse complies with the copyright policies of the owner of that content.
- If article content is copied, downloaded, or otherwise reused for non-commercial research and education purposes, a link to the appropriate bibliographic citation (authors, journal, article title, volume, issue, page numbers, DOI, and the link to the definitive published version on JKAS website) should be maintained.
- Copyright notices and disclaimers must not be deleted.
- Any translations, for which a prior translation agreement with JKAS has not been agreed, must prominently display the statement: "This is an unofficial translation of an article that appeared in an FSP publication. The publisher has not endorsed this translation."
Use by commercial "for-profit" organizations
Use of JKAS Open Access articles for commercial, promotional, or marketing purposes requires further explicit permission from JKAS (journal.agri@uokerbala.edu.iq) and will be subject to a fee.
The commercial purposes include:
Copying or downloading of articles, or linking to such articles for further redistribution, sale, or licensing; Copying, downloading, or posting by a site or service that incorporates advertising with such content; The inclusion, or incorporation of article content in other works, or services (other than normal quotations with an appropriate citation) that is then available for sale or licensing, for a fee (for example, a compilation produced for marketing purposes, inclusion in a sales pack); Use of article content (other than normal quotations with appropriate citation) by for-profit organizations for promotional purposes; Linking to article content in e-mails redistributed for promotional, marketing or educational purposes; Use for the purposes of monetary reward by means of sale, resale, license, loan, transfer or other form of commercial exploitation such as marketing products; Print reprints of articles can be purchased from journal.agri@uokerbala.edu.iq.
Permissions
- No special permission is required to reuse all, or part of the article published by JKAS, including figures and tables for non-commercial purposes.
- Any part of the article may be reused, for non-commercial purposes, without permission provided that the original article is cited.
- Reuse of an article does not imply endorsement by the authors, JKAS
