Effect of Coenzyme Q10 on the reproductive system of female rats (Rattus norvegicus ) treated with lead acetate
DOI:
https://doi.org/10.59658/jkas.v4i5.701Keywords:
Coenzyme Q10, lead acetate ,reproductive system, مرافق الانزيم Q10,خلات الرصاص ,الجهاز التكاثريAbstract
This study was conducted to evaluate the effectiveness of the CoQ10 on the reproductive system of female rats and it's ability to reduce the harmful effect of lead acetate. To achieve this goal an experiment was done on 24 mature female rats which are randomly divided into 4 groups, group(1) treated with 1ml/kg corn oil and considered as a negative control group, group(2) treated with CoQ10 at dose 200 mg/kg and considered as a positive control group, group(3) treated with lead acetate at dose 8mg /kg ,and group (4) treated with lead acetate for 30 days then after CoQ10 for another 30 days. Blood samples were taken from all animals after 60 days for biochemical analysis to estimate FSH, LH, estrogen and progesterone hormones .Histological examinations of an ovary and uterus were also involved in this study. Results showed a significant increase (p< 0.05) in serum FSH, estrogen and progesterone levels in group(2) compared to other groups while LH level was significantly increased (p< 0.05) compared to group (3). Group( 3) showed a significant decrease (p< 0.05) in serum FSH, LH level in compared to group (1) and group( 4 ),while progesterone and estrogen levels showed no significant difference (p> 0.05) compared to group(1) . At the same time, there were no significant difference (p> 0.05) in serum LH, estrogen and progesterone levels in group (4) compared to group(1), while there was a significant decrease (p< 0.05) in serum FSH level in group(4) compared group(1). The results of ovary sections ,group( 2) showed normal structure and distribution pattern of various ovary components, while group (3)showed sever hemorrhage in the ovarian stroma and suppression of ovarian follicles. Group(4) showed particular recovery in ovarian parenchyma. Uterus sections of group(2) showed normal epithelium which lining the uterus and there is destitution uterine glands. Group(3) showed epithelium degenerative, small and non developed uterine glands and hemorrhage in uterine tissue .Other wised uterus in group (4)showed normal columnar epithelium which lining the uterus, and proliferation of uterine glands.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2017 Journal of Kerbala for Agricultural Sciences
This work is licensed under a Creative Commons Attribution 4.0 International License.
Licensing Terms
All articles are published under a Creative Commons License and will be directed to the Creative Commons Attribution 4.0 International License That permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Use by non-commercial users
For non-commercial and non-promotional purposes individual users may access, download, copy, display, and redistribute the articles to colleagues, as well as adapt, translate, text- and data-mine the content subject to the following conditions:
- The author's moral rights are not compromised. These rights include the right of "paternity" (also known as "attribution" - the right for the author to be identified as such) and "integrity" (the right for the author not to have the work altered in such a way that the author's reputation, or integrity may be impugned).
- Where content in the article is identified as belonging to a third party, it is the obligation of the user to ensure that any reuse complies with the copyright policies of the owner of that content.
- If article content is copied, downloaded, or otherwise reused for non-commercial research and education purposes, a link to the appropriate bibliographic citation (authors, journal, article title, volume, issue, page numbers, DOI, and the link to the definitive published version on JKAS website) should be maintained.
- Copyright notices and disclaimers must not be deleted.
- Any translations, for which a prior translation agreement with JKAS has not been agreed, must prominently display the statement: "This is an unofficial translation of an article that appeared in an FSP publication. The publisher has not endorsed this translation."
Use by commercial "for-profit" organizations
Use of JKAS Open Access articles for commercial, promotional, or marketing purposes requires further explicit permission from JKAS (journal.agri@uokerbala.edu.iq) and will be subject to a fee.
The commercial purposes include:
Copying or downloading of articles, or linking to such articles for further redistribution, sale, or licensing; Copying, downloading, or posting by a site or service that incorporates advertising with such content; The inclusion, or incorporation of article content in other works, or services (other than normal quotations with an appropriate citation) that is then available for sale or licensing, for a fee (for example, a compilation produced for marketing purposes, inclusion in a sales pack); Use of article content (other than normal quotations with appropriate citation) by for-profit organizations for promotional purposes; Linking to article content in e-mails redistributed for promotional, marketing or educational purposes; Use for the purposes of monetary reward by means of sale, resale, license, loan, transfer or other form of commercial exploitation such as marketing products; Print reprints of articles can be purchased from journal.agri@uokerbala.edu.iq.
Permissions
- No special permission is required to reuse all, or part of the article published by JKAS, including figures and tables for non-commercial purposes.
- Any part of the article may be reused, for non-commercial purposes, without permission provided that the original article is cited.
- Reuse of an article does not imply endorsement by the authors, JKAS