Protective Role of Pomegranate peel extract on the Pituitary gland of adult male rabbits treated with CCL4
DOI:
https://doi.org/10.59658/jkas.v4i5.695Abstract
This study was carried out to investigate the protective role of pomegranate peel extract for relieving the harmful effects of carbon tetrachloride on the pituitary gland function in adult male rabbits. Twenty four adult male rabbits were used in this study and divided randomly into four equal groups. Rabbits of the 1st group were received 1 ml of orally distal water once a day and olive oil 1/2 ml /kg B.W. intraperitoneal injection [I.P] twice a week as a control group. The second group were treated I.P with 500 mg / kg B.W. of CCL4 mixing with equal volume of olive oil (o.5 ml/kg B.W.) twice a week (group T1). The third group were received orally pomegranate peel extract (100 mg/kg B.W) once a day and olive oil 1/2 ml /kg B.W. I.P twice a week ( group T2). The fourth group were received pomegranate peel extract (100 mg/kg B.W) once a day and treated I.P with 500 mg / kg B.W. of CCL4 mixing with equal volume of olive oil (o.5 ml/kg B.W.) twice a week (group T3). Blood samples were collected at on days (0, 14, 28.42 and 56) for measuring LH, FSH concentrations, total serum protein after treatment. Results showed a significant (P<0.05) decrease in total serum protein in T1 group compared with control group. While T2 group showed a significant (P<0.05) increase in these parameter as compared with the control and T1 group at the end of treatment period. T1 group indicated i a significant (P<0.05) increase in serum LH at(zero and 14 day) and FSH at( from zero time to the 28 day) . These levels, however, were significantly decreased in T1 group compared to what we observed in the control ones at the end of the experiment period. T2 group also showed a significant (P<0.05) increase in serum FSH at (24 day to the 56day of experiment) and LH concentration (at 56 day) compared to control group. Histological study was showed sever congestion of blood vessel and necrotic area in section of anterior pituitary gland in group treated with CCL4, while demonstrate moderate congestion in T3 group.
In conclusion, Pomegranate peel extract at dose (100 mg/kg B.W.) has positive effects on the pituitary gland function, hence eliminating the deleterious effects or toxic effect of CCL4.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2017 Journal of Kerbala for Agricultural Sciences
This work is licensed under a Creative Commons Attribution 4.0 International License.
Licensing Terms
All articles are published under a Creative Commons License and will be directed to the Creative Commons Attribution 4.0 International License That permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Use by non-commercial users
For non-commercial and non-promotional purposes individual users may access, download, copy, display, and redistribute the articles to colleagues, as well as adapt, translate, text- and data-mine the content subject to the following conditions:
- The author's moral rights are not compromised. These rights include the right of "paternity" (also known as "attribution" - the right for the author to be identified as such) and "integrity" (the right for the author not to have the work altered in such a way that the author's reputation, or integrity may be impugned).
- Where content in the article is identified as belonging to a third party, it is the obligation of the user to ensure that any reuse complies with the copyright policies of the owner of that content.
- If article content is copied, downloaded, or otherwise reused for non-commercial research and education purposes, a link to the appropriate bibliographic citation (authors, journal, article title, volume, issue, page numbers, DOI, and the link to the definitive published version on JKAS website) should be maintained.
- Copyright notices and disclaimers must not be deleted.
- Any translations, for which a prior translation agreement with JKAS has not been agreed, must prominently display the statement: "This is an unofficial translation of an article that appeared in an FSP publication. The publisher has not endorsed this translation."
Use by commercial "for-profit" organizations
Use of JKAS Open Access articles for commercial, promotional, or marketing purposes requires further explicit permission from JKAS (journal.agri@uokerbala.edu.iq) and will be subject to a fee.
The commercial purposes include:
Copying or downloading of articles, or linking to such articles for further redistribution, sale, or licensing; Copying, downloading, or posting by a site or service that incorporates advertising with such content; The inclusion, or incorporation of article content in other works, or services (other than normal quotations with an appropriate citation) that is then available for sale or licensing, for a fee (for example, a compilation produced for marketing purposes, inclusion in a sales pack); Use of article content (other than normal quotations with appropriate citation) by for-profit organizations for promotional purposes; Linking to article content in e-mails redistributed for promotional, marketing or educational purposes; Use for the purposes of monetary reward by means of sale, resale, license, loan, transfer or other form of commercial exploitation such as marketing products; Print reprints of articles can be purchased from journal.agri@uokerbala.edu.iq.
Permissions
- No special permission is required to reuse all, or part of the article published by JKAS, including figures and tables for non-commercial purposes.
- Any part of the article may be reused, for non-commercial purposes, without permission provided that the original article is cited.
- Reuse of an article does not imply endorsement by the authors, JKAS