The Antioxidative Action of Dehydroepandrosterone (DHEA) on the Testicular Histology in adult mice treated with two doses of Nitrofu-rantoin

Authors

  • Tahani S.S. Al-Azawi Dept.of Physiology&Pharmacology/College of Veterinary Medicine University of Baghdad
  • Mohammed H. Asker Dept.of Physiology&Pharmacology/College of Veterinary Medicine University of Baghdad

DOI:

https://doi.org/10.59658/jkas.v4i5.693

Keywords:

Nitrofurantoin, DHEA, male fertility, Histology

Abstract

The antioxidant role of Dehydroepiandrosterone(DHEA) was investigated against  two dose of Nitrofurantoin (NFT). Seventy-two adult albino mice were divided in to six equal groups. (G1) control, (G2) received 2 mg/kg B.w of DHEA, (G3) received oral dose of 1.5 mg/kg B.W NFT, (G4) received oral dose of 3 mg/kg B.W of NFT,(G5) received DHEA and 1.5 mg kg/B.w NFT and (G6) received DHEA and 3 mg/kg B.w NFT. Histopathological examination of testes was studied after 30 and 60 day of the experiment and revealed a great number of testicular damage including interstitial hemorrhage and vacuoles, abnormal immature spermatozoa, atrophy in germ cells with severe damage and necrosis of tubules in Nitrofuantoin treated mice. In conclusion, this study showed that NFT has deleterious effect on the reproductive function of male mice and DHEA can protect this system against this harmful effect induced  by NFT through its antioxidative activity.

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Published

04/10/2017

How to Cite

Al-Azawi, T. S., & Asker, M. H. (2017). The Antioxidative Action of Dehydroepandrosterone (DHEA) on the Testicular Histology in adult mice treated with two doses of Nitrofu-rantoin. Journal of Kerbala for Agricultural Sciences, 4(5), 58–67. https://doi.org/10.59658/jkas.v4i5.693

Issue

Vol. 4 No. 5 (2017): Proceedings of the Third Scientific Conference of the Faculty of Veterinary Medicine / University of Kerbala on 10th April 2017

Section

Proceedings of the Third Scientific Conference of the Faculty of Veterinary Med

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Copyright (c) 2017 Journal of Kerbala for Agricultural Sciences

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